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Clinical and Vaccine Immunology, March 2008, p. 579-581, Vol. 15, No. 3
1071-412X/08/$08.00+0     doi:10.1128/CVI.00359-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Humoral Immune Responses of Tuberculosis Patients in Brazil Indicate Recognition of Mycobacterium tuberculosis MPT-51 and GlcB{triangledown}

Cristina Melo Cardoso Almeida,1 Arioldo C. Vasconcelos Jr.,1 André Kipnis,2 Ana Lúcia Andrade,3 and Ana Paula Junqueira-Kipnis1*

Departamento de Microbiologia, Imunologia, Parasitologia e Patologia, Laboratório de Imunopatologia das Doenças Infecciosas,1 Laboratório de Bacteriologia Molecular,2 Departamento de Saúde Coletiva, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia-Go, Brasil3

Received 3 September 2007/ Returned for modification 2 October 2007/ Accepted 8 January 2008

The humoral responses to recombinant MPT-51 and GlcB was determined by using an enzyme-linked immunosorbent assay. Levels of immunoglobulin M (IgM) against MPT-51 and IgG against GlcB were higher among tuberculosis (TB) patients than among control individuals. When the MPT-51 and GlcB assays were combined, 90.8% specificity and 75.5% sensitivity were observed. MPT-51 and GlcB were recognized in the humoral responses of Brazilian TB patients.

* Corresponding author. Mailing address: Rua Delenda Rezende de Melo S/N, Setor Universitário, 74605-050 Goiânia-Goiás, Brazil. Phone: 55 11 62 32096126. Fax: 55 11 62 35211839. E-mail: anapaula{at}iptsp.ufg.br

{triangledown} Published ahead of print on 16 January 2008.

Clinical and Vaccine Immunology, March 2008, p. 579-581, Vol. 15, No. 3
1071-412X/08/$08.00+0     doi:10.1128/CVI.00359-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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