This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stayoussef, M.
Right arrow Articles by Almawi, W. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stayoussef, M.
Right arrow Articles by Almawi, W. Y.

 Previous Article  |  Next Article 

Clinical and Vaccine Immunology, February 2008, p. 379-381, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00410-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Modulation of Type 1 Diabetes Susceptibility by Tumor Necrosis Factor Alpha –308 G/A and Lymphotoxin Alpha +249 A/G Haplotypes and Lack of Linkage Disequilibrium with Predisposing DQB1-DRB1 Haplotypes in Bahraini Patients{triangledown}

Mouna Stayoussef,1 Fayza A. Al-Jenaidi,2,3 Abduljabbar Al-Abbasi,2,3 Khadija Al-Ola,3 Haya Khayyat,4 Touhami Mahjoub,1 and Wassim Y. Almawi2*

University of Monastir, Monastir, Tunisia,1 College of Medicine and Medical Sciences, Arabian Gulf University,2 Department of Pediatrics, Salmaniya Medical Complex, Manama, Bahrain,3 Bahrain Defense Forces Hospital, Rifaa, Bahrain4

Received 9 October 2007/ Accepted 25 October 2007

Tumor necrosis factor alpha (TNF-{alpha}) –308 G/A and lymphotoxin alpha (LT{alpha}) +249 A/G single-nucleotide polymorphisms were investigated in 228 type 1 diabetes mellitus (T1DM) patients and 240 controls. Only LT{alpha} +249G allele and +249G/+249G genotype frequencies were higher among patients, and no linkage disequilibrium was found between TNF-{alpha}/LT{alpha} alleles and susceptible/protective DRB1-DQB1 haplotypes. TNF-{alpha}/LT{alpha} T1DM-susceptible (–308G/+249G) and protective (–308G/+249A) haplotypes were identified.

* Corresponding author. Mailing address: Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 22979, Manama, Bahrain. Phone: 973-39717118. Fax: 973-17271090. E-mail: wyalmawi{at}yahoo.co.uk

{triangledown} Published ahead of print on 7 November 2007.

Clinical and Vaccine Immunology, February 2008, p. 379-381, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00410-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»