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Clinical and Vaccine Immunology, February 2008, p. 376-378, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00285-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Induction of Antitumor Acquired Immunity by Baculovirus Autographa californica Multiple Nuclear Polyhedrosis Virus Infection in Mice{triangledown}

Masayuki Kitajima1,3 and Hiroshi Takaku1,2*

Department of Life and Environmental Sciences,1 High Technology Research Center, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba 275-0016, Japan,2 Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba 260-8670, Japan3

Received 9 July 2007/ Returned for modification 15 October 2007/ Accepted 19 November 2007

The baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) has been studied as a gene therapy vector. Here, we demonstrated that AcMNPV induces antitumor acquired immunity. These results suggest that AcMNPV has the potential to be an efficient virus or tumor therapy agent which induces innate and acquired immunity.

* Corresponding author. Mailing address: Department of Life and Environmental Sciences and High Technology Research Center, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba, Japan. Phone: 81-47-478-0407. Fax: 81-47-471-8764. E-mail: hiroshi.takaku{at}it-chiba.ac.jp

{triangledown} Published ahead of print on 5 December 2007.

Clinical and Vaccine Immunology, February 2008, p. 376-378, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00285-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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