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Clinical and Vaccine Immunology, November 2008, p. 1745-1748, Vol. 15, No. 11
1071-412X/08/$08.00+0     doi:10.1128/CVI.00247-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Potentially Exposed but Uninfected Individuals Produce Cytotoxic and Polyfunctional Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Which Can Be Defined to the Epitope Level {triangledown}

A. L. Erickson,1 C. B. Willberg,1 V. McMahan,2 A. Liu,3 S. P. Buchbinder,3 L. A. Grohskopf,4 R. M. Grant,2 and D. F. Nixon1*

Division of Experimental Medicine, Department of Medicine, UCSF, San Francisco, California 94110,1 Gladstone Institute of Virology and Immunology, UCSF, San Francisco, California 94158,2 Division of VCF and Epidemiology, Department of Medicine, UCSF, San Francisco, California 94143,3 Epidemiology Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 303334

Received 10 July 2008/ Returned for modification 6 August 2008/ Accepted 8 September 2008

We measured CD8+ T-cell responses in 12 potentially exposed but uninfected men who have sex with men by using cytokine flow cytometry. Four of the individuals screened exhibited polyfunctional immune responses to human immunodeficiency virus type 1 Gag or Vif. The minimum cytotoxic T lymphocyte epitope was mapped in one Gag responder.

* Corresponding author. Mailing address: Division of Experimental Medicine, Department of Medicine, UCSF, San Francisco, CA 94110. Phone: (415) 206-5518. Fax: (415) 206-5581. E-mail: douglas.nixon{at}ucsf.edu

{triangledown} Published ahead of print on 24 September 2008.

Clinical and Vaccine Immunology, November 2008, p. 1745-1748, Vol. 15, No. 11
1071-412X/08/$08.00+0     doi:10.1128/CVI.00247-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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