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Clinical and Vaccine Immunology, November 2008, p. 1742-1744, Vol. 15, No. 11
1071-412X/08/$08.00+0     doi:10.1128/CVI.00255-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Enhanced Gamma Interferon Responses of Mouse Spleen Cells following Immunotherapy for Tuberculosis Relapse {triangledown}

Olga Gil,1,2 Cristina Vilaplana,1,2 Evelyn Guirado,1,2 Jorge Díaz,1,2 Neus Cáceres,1 Mahavir Singh,3 and Pere-Joan Cardona1,2*

Unitat de Tuberculosi Experimental, Department of Microbiology, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Crta de can Ruti s/n, 08916, Badalona, Catalonia, Spain,1 CIBER Enfermedades Respiratorias, Palma de Mallorca, Spain,2 Lionex Diagnostics and Therapeutics GMBH, Braunschweig, Germany3

Received 15 July 2008/ Returned for modification 4 September 2008/ Accepted 19 September 2008

Gamma interferon responses of spleen cells in mice were examined during postchemotherapy relapse of intraperitoneally induced latent tuberculous infection. The mycobacterial extract RUTI, which prevented the relapse, significantly enhanced the immune responses to secreted and structural recombinant mycobacterial antigens, suggesting that RUTI-mediated protection was mediated by activated T cells.

* Corresponding author. Mailing address: Unitat de Tuberculosi Experimental, Department of Microbiology, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Crta de can Ruti, Camí de les Escoles s/n, 08916 Badalona, Catalonia, Spain. Phone: 34 93 497 86 86. Fax: 34 93 497 86 54. E-mail: pjcardona.igtp.germanstrias{at}gencat.cat

{triangledown} Published ahead of print on 30 September 2008.

Clinical and Vaccine Immunology, November 2008, p. 1742-1744, Vol. 15, No. 11
1071-412X/08/$08.00+0     doi:10.1128/CVI.00255-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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