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Clinical and Vaccine Immunology, October 2008, p. 1536-1540, Vol. 15, No. 10
1071-412X/08/$08.00+0     doi:10.1128/CVI.00197-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Neutralizing Antibodies against Human Papillomavirus Types 16, 18, 31, 52, and 58 in Serum Samples from Women in Japan with Low-Grade Cervical Intraepithelial Neoplasia{triangledown}

Hiroyuki Ochi,1,2,{dagger} Kazunari Kondo,1,2,{dagger} Koji Matsumoto,2 Akinori Oki,2 Toshiharu Yasugi,3 Reiko Furuta,4 Yasuo Hirai,5 Hiroyuki Yoshikawa,2 and Tadahito Kanda1*

Center for Pathogen Genomics, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan,1 Department of Obstetrics and Gynecology, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba City, Ibaraki 305-8575, Japan,2 Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan,3 Department of Pathology, Cancer Institute,4 Departments of Gynecology and Cytopathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo 135-8550, Japan5

Received 29 May 2008/ Returned for modification 28 July 2008/ Accepted 18 August 2008

We have very limited information on serum neutralizing antibody in women naturally infected with the human papillomaviruses (HPVs) that are causally associated with cervical cancer. In this study, serum samples collected from 217 Japanese women with low-grade cervical intraepithelial neoplasia were examined for their neutralizing activities against HPV16, -18, -31, -52, and -58 pseudovirions. Eighty-four patients (39%), 35 patients (16%), 17 patients (8%), and 1 patient were positive for neutralizing antibodies against one, two, three, and four of these types, respectively. Presence of neutralizing antibody did not always correlate with detection of HPV DNA in cervical swabs collected at the time of blood collection. The neutralizing titers of the majority of sera, ranging between 40 and 640, were found to be conserved in the second sera, collected 24 months later, independently of emergence of HPV DNA in the second cervical swabs. The data strongly suggest that HPV infection induces anti-HPV neutralizing antibody at low levels, which are maintained for a long period of time.

* Corresponding author. Mailing address: Center for Pathogen Genomics, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Phone: 81-3-5285-1111, ext. 2524. Fax: 81-3-5285-1166. E-mail: kanda{at}nih.go.jp

{triangledown} Published ahead of print on 27 August 2008.

{dagger} These authors contributed equally to this work.

Clinical and Vaccine Immunology, October 2008, p. 1536-1540, Vol. 15, No. 10
1071-412X/08/$08.00+0     doi:10.1128/CVI.00197-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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