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Clinical and Vaccine Immunology, January 2008, p. 168-171, Vol. 15, No. 1
1071-412X/08/$08.00+0     doi:10.1128/CVI.00364-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Comparison of Two Commercially Available Gamma Interferon Blood Tests for Immunodiagnosis of Tuberculosis{triangledown}

Jose Domínguez,1,3,4* Juan Ruiz-Manzano,2,3,4 Malú De Souza-Galvão,3,5 Irene Latorre,1,3,4 Celia Milà,5 Silvia Blanco,1,3,4 M. Ángeles Jiménez,5 Cristina Prat,1,3,4 Alicia Lacoma,1,3 Neus Altet,5 and Vicente Ausina1,3,4

Servei de Microbiologia,1 Servei de Pneumologia, Hospital Universitari Germans Trias i Pujol, Fundació Institut en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain,2 Universitat Autònoma de Barcelona, Bellaterra, Spain,3 Ciber Enfermedades Respiratorias, Instituto de Salud Carlos III, Badalona, Spain,4 Unidad de Prevención y Control de la Tuberculosis de Barcelona, Barcelona, Spain5

Received 22 August 2007/ Returned for modification 3 October 2007/ Accepted 21 October 2007

We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases.

* Corresponding author. Mailing address: Servei de Microbiologia, Fundació Institut en Ciències de la Salut Germans Trias i Pujol, Carretera del Canyet s/n, 08916 Badalona, Barcelona, Spain. Phone: 34 93 497 88 94. Fax: 34 93 497 88 95. E-mail: jadominguez.igtp.germanstrias{at}gencat.net

{triangledown} Published ahead of print on 31 October 2007.

Clinical and Vaccine Immunology, January 2008, p. 168-171, Vol. 15, No. 1
1071-412X/08/$08.00+0     doi:10.1128/CVI.00364-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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