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 Previous Article

Clinical and Vaccine Immunology, August 2007, p. 1053-1055, Vol. 14, No. 8
1071-412X/07/$08.00+0     doi:10.1128/CVI.00173-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Seroprevalence of Neutralizing Antibodies to Adenovirus Type 5 among Children in India: Implications for Recombinant Adenovirus-Based Vaccines{triangledown}

Mohan Babu Appaiahgari,1 Ravindra Mohan Pandey,2 and Sudhanshu Vrati1*

National Institute of Immunology, New Delhi 110 067, India,1 Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 110 016, India2

Received 13 April 2007/ Returned for modification 30 May 2007/ Accepted 14 June 2007

We determined the levels of adenovirus 5 (Ad5) neutralizing antibodies in children in India less than 2 years of age. The results clearly show an age-dependent increase in Ad5-specific immunity, with 7- to 12-month-old children having the lowest levels of Ad5 immunity. This opens up the scope for the use of recombinant Ad5-based vaccines in this age group.

* Corresponding author. Mailing address: National Institute of Immunology, Aruna saf Ali Marg, JNU Complex, New Delhi 110067, India. Phone: 91-11-26703696. Fax: 91-11-26162125. E-mail: vrati{at}nii.res.in

{triangledown} Published ahead of print on 27 June 2007.

Clinical and Vaccine Immunology, August 2007, p. 1053-1055, Vol. 14, No. 8
1071-412X/07/$08.00+0     doi:10.1128/CVI.00173-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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