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Clinical and Vaccine Immunology, July 2007, p. 924-925, Vol. 14, No. 7
1071-412X/07/$08.00+0     doi:10.1128/CVI.00025-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Quantification of 1,3-β-D-Glucan Levels in Children: Preliminary Data for Diagnostic Use of the β-Glucan Assay in a Pediatric Setting{triangledown}

P. Brian Smith,1,2 Daniel K. Benjamin Jr.,1,2 Barbara D. Alexander,3 Melissa D. Johnson,3 Malcolm A. Finkelman,4 and William J. Steinbach1,5*

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina,1 Duke University Clinical Research Institute, Durham, North Carolina,2 Department of Medicine, Duke University Medical Center, Durham, North Carolina,3 Associates of Cape Cod, Inc., Falmouth, Massachusetts,4 Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina5

Received 11 January 2007/ Returned for modification 5 March 2007/ Accepted 16 May 2007

1,3-β-D-Glucan serum levels have demonstrated good diagnostic sensitivity and specificity for the diagnosis of candidiasis in adult patients, but normal levels for children have not been established. We found higher 1,3-β-D-glucan levels in children than those previously reported in adults.

* Corresponding author. Mailing address: Division of Pediatric Infectious Diseases, Box 3499, Duke University Medical Center, Durham, NC 27710. Phone: (919) 681-1504. Fax: (919) 684-8902. E-mail: stein022{at}mc.duke.edu

{triangledown} Published ahead of print on 30 May 2007.

Clinical and Vaccine Immunology, July 2007, p. 924-925, Vol. 14, No. 7
1071-412X/07/$08.00+0     doi:10.1128/CVI.00025-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Petraitiene, R., Petraitis, V., Hope, W. W., Mickiene, D., Kelaher, A. M., Murray, H. A., Mya-San, C., Hughes, J. E., Cotton, M. P., Bacher, J., Walsh, T. J. (2008). Cerebrospinal Fluid and Plasma (1->3)-{beta}-D-Glucan as Surrogate Markers for Detection and Monitoring of Therapeutic Response in Experimental Hematogenous Candida Meningoencephalitis. Antimicrob. Agents Chemother. 52: 4121-4129 [Abstract] [Full Text]  


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