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Clinical and Vaccine Immunology, June 2007, p. 789-791, Vol. 14, No. 6
1071-412X/07/$08.00+0     doi:10.1128/CVI.00082-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Immunization with PspA Incorporated into a Poly(Ethylene Oxide) Matrix Elicits Protective Immunity against Streptococcus pneumoniae{triangledown}

Quincy C. Moore III,1 LaShundra Johnson,1 Michael Repka,4 and Larry S. McDaniel1,2,3*

Departments of Microbiology,1 Surgery,2 Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216,3 Department of Pharmaceutics, The University of Mississippi, University, Mississippi 386774

Received 14 February 2007/ Returned for modification 27 March 2007/ Accepted 17 April 2007

CBA/N mice were immunized with PspA in a poly(ethylene oxide) matrix to examine its ability to deliver the antigen and modulate the immune response. All mice receiving PspA in the matrix survived a lethal pneumococcal challenge and had serum anti-PspA antibody levels statistically higher than mice receiving PspA alone (P < 0.009).

* Corresponding author. Mailing address: Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216. Phone: (601) 984-6880. Fax: (601) 984-1708. E-mail: LmcDaniel{at}microbio.umsmed.edu

{triangledown} Published ahead of print on 25 April 2007.

Clinical and Vaccine Immunology, June 2007, p. 789-791, Vol. 14, No. 6
1071-412X/07/$08.00+0     doi:10.1128/CVI.00082-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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