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Clinical and Vaccine Immunology, May 2007, p. 638-640, Vol. 14, No. 5
1071-412X/07/$08.00+0     doi:10.1128/CVI.00479-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Histoplasmosis-Associated Cross-Reactivity in the BioRad Platelia Aspergillus Enzyme Immunoassay{triangledown}

L. Joseph Wheat,1* Emily Hackett,1 Michelle Durkin,1 Patricia Connolly,1 Ruta Petraitiene,2,3 Thomas J. Walsh,2 Kenneth Knox,4 and Chadi Hage4

MiraVista Diagnostics, Indianapolis, Indiana,1 National Cancer Institute, Pediatric Oncology Branch, Immunocompromised Host Section, CRC, Rm. 1W-5750, 10 Center Drive, Bethesda, Maryland 20892-1100,2 Laboratory Animal Sciences Program, SAIC-Frederick, Inc., Frederick, Maryland 21702,3 Indiana University School of Medicine, Department of Pulmonary Medicine, Roudebush Veterans' Administration Hospital, 1481 West Tenth Street, Indianapolis, Indiana 462024

Received 19 December 2006/ Returned for modification 24 January 2007/ Accepted 8 February 2007

We observed false-positive results in the Platelia Aspergillus enzyme-linked immunoassay (EIA) for specimens from patients with histoplasmosis and mice with experimental infection. Platelia Aspergillus EIA-positive specimens were negative in the second-generation Histoplasma antigen EIA. Care must be taken to exclude histoplasmosis for patients with positive Platelia Aspergillus EIA results.

* Corresponding author. Mailing address: MiraVista Diagnostics, 4444 Decatur Blvd., Suite 300, Indianapolis, IN 46241. Phone: (317) 856-2681. Fax: (317) 856-3685. E-mail: jwheat{at}miravistalabs.com

{triangledown} Published ahead of print on 7 March 2007.

Clinical and Vaccine Immunology, May 2007, p. 638-640, Vol. 14, No. 5
1071-412X/07/$08.00+0     doi:10.1128/CVI.00479-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Xavier, M. O., Pasqualotto, A. C., Cardoso, I. C. E., Severo, L. C. (2009). Cross-Reactivity of Paracoccidioides brasiliensis, Histoplasma capsulatum, and Cryptococcus Species in the Commercial Platelia Aspergillus Enzyme Immunoassay. CVI 16: 132-133 [Abstract] [Full Text]  
  • Zhuang, D., Hage, C., De Jesus, M., Hackett, E., Durkin, M., Davis, T. E., Casadevall, A., Wheat, L. J. (2008). Cryptococcal Glucoxylomannan Does Not Exhibit Cross-Reactivity in the MVista Histoplasma Antigen Enzyme Immunoassay. CVI 15: 392-393 [Abstract] [Full Text]  
  • Cloud, J. L., Bauman, S. K., Pelfrey, J. M., Ashwood, E. R., Wheat, L. J., LeMonte, A. (2007). Biased Report on the IMMY ALPHA Histoplasma Antigen Enzyme Immunoassay for Diagnosis of Histoplasmosis. CVI 14: 1389-1391 [Full Text]  


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