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Clinical and Vaccine Immunology, May 2007, p. 628-634, Vol. 14, No. 5
1071-412X/07/$08.00+0     doi:10.1128/CVI.00409-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

OspC Phylogenetic Analyses Support the Feasibility of a Broadly Protective Polyvalent Chimeric Lyme Disease Vaccine{triangledown}

Christopher G. Earnhart1 and Richard T. Marconi1,2*

Department of Microbiology and Immunology,1 Center for the Study of Biological Complexity, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298-06782

Received 1 November 2006/ Returned for modification 18 January 2007/ Accepted 5 March 2007

Using available Borrelia outer surface protein C (OspC) sequences, a phylogenetic analysis was undertaken to delineate the number of antigenic domains required for inclusion in a broadly protective, chimeric, OspC-based Lyme disease vaccine. The data indicate that approximately 34 would be required and that an OspC-based vaccinogen is feasible.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298-0678. Phone: (804) 828-3888. Fax: (804) 827-1548. E-mail: rmarconi{at}vcu.edu

{triangledown} Published ahead of print on 14 March 2007.

Clinical and Vaccine Immunology, May 2007, p. 628-634, Vol. 14, No. 5
1071-412X/07/$08.00+0     doi:10.1128/CVI.00409-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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Copyright © 2007 by the American Society for Microbiology. All rights reserved.