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Clinical and Vaccine Immunology, May 2007, p. 624-627, Vol. 14, No. 5
1071-412X/07/$08.00+0     doi:10.1128/CVI.00368-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Galactoxylomannan Does Not Exhibit Cross-Reactivity in the Platelia Aspergillus Enzyme Immunoassay{triangledown}

Magdia De Jesus,1 Emily Hackett,2 Michelle Durkin,2 Patricia Connolly,2 Arturo Casadevall,1 Ruta Petraitiene,3,4 Thomas J. Walsh,3 and L. Joseph Wheat2*

Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forchheimer 411, Bronx, New York 10461,1 MiraVista Diagnostics, Indianapolis, Indiana,2 Pediatric Oncology Branch, Immunocompromised Host Section, National Cancer Institute, CRC, Room 1W-5750, 10 Center Drive, Bethesda, Maryland 20892-1100,3 Laboratory Animal Sciences Program, SAIC-Frederick, Inc., Frederick, Maryland 217024

Received 6 October 2006/ Returned for modification 24 January 2007/ Accepted 22 February 2007

Given the recent report of a false-positive result in the Platelia Aspergillus enzyme immunoassay in a patient with cryptococcosis and in yeast extracts and purified galactoxylomannan of Cryptococcus neoformans, we evaluated culture extracts, purified polysaccharides, clinical specimens, and specimens from animals following experimental infection. Our results revealed no cross-reactions.

* Corresponding author. Mailing address: MiraVista Diagnostics, 4444 Decatur Blvd., Suite 300, Indianapolis, IN 46241. Phone: (317) 856-2681. Fax: (317) 856-3685. E-mail: jwheat{at}miravistalabs.com

{triangledown} Published ahead of print on 14 March 2007.

Clinical and Vaccine Immunology, May 2007, p. 624-627, Vol. 14, No. 5
1071-412X/07/$08.00+0     doi:10.1128/CVI.00368-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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