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Clinical and Vaccine Immunology, April 2007, p. 470-473, Vol. 14, No. 4
1071-412X/07/$08.00+0     doi:10.1128/CVI.00428-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Limited Protection Conferred by a DNA Vaccine against a Lethal Pseudorabies Virus Infection at Day 5 Postvaccination{triangledown}

Daniel Dory,1* Anne-Marie Torché,1 Véronique Béven,1 Roland Cariolet,2 and André Jestin1

Viral Genetics and Biosafety Unit, French Food Safety Agency (Afssa), Fr-22440 Ploufragan, France,1 Healthy Pigs Production and Experimentation Section, Afssa, Fr-22440 Ploufragan, France2

Received 16 November 2006/ Returned for modification 18 December 2006/ Accepted 1 February 2007

No pseudorabies virus (PRV)-specific neutralizing or immunoglobulin G1-type antibodies were detected in sera 5 days after injection of a DNA vaccine against PRV infection in pigs. PRV-stimulated peripheral blood mononuclear cells produced gamma interferon mRNA in vitro. Two out of five pigs recovered from lethal PRV infection without attenuation of nasal viral excretion.

* Corresponding author. Mailing address: Viral Genetics and Biosafety Unit, Afssa (French Food Safety Agency), BP-53, Fr-22440 Ploufragan, France. Phone: 00 33 2 96 01 64 42. Fax: 00 33 2 96 01 62 83. E-mail: d.dory{at}ploufragan.afssa.fr

{triangledown} Published ahead of print on 14 February 2007.

Clinical and Vaccine Immunology, April 2007, p. 470-473, Vol. 14, No. 4
1071-412X/07/$08.00+0     doi:10.1128/CVI.00428-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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