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Clinical and Vaccine Immunology, March 2007, p. 318-319, Vol. 14, No. 3
1071-412X/07/$08.00+0     doi:10.1128/CVI.00396-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Evaluation of a Novel Enzyme-Linked Immunosorbent Assay To Detect Immunoglobulin G Antibody to Enolase for Serodiagnosis of Invasive Candidiasis{triangledown}

Ana Laín,1 María D. Moragues,2 Juan Carlos García Ruiz,3 Joaquín Mendoza,4 Ana Camacho,4 Amalia del Palacio,5 and José Pontón1*

Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología,1 Departamento de Enfermería I, Universidad del País Vasco, Apartado 699, E-48080 Bilbao, Vizcaya, Spain,2 Servicio de Hematología, Hospital de Cruces, Baracaldo, Vizcaya, Spain,3 Laboratorios Vircell SL, Granada, Spain,4 Servicio de Microbiología, Unidad de Micología, Hospital Universitario Doce de Octubre, Madrid, Spain5

Received 17 October 2006/ Returned for modification 22 December 2006/ Accepted 4 January 2007

The performance of a new test to detect antibodies to Candida albicans recombinant enolase was investigated in 47 immunocompromised and 51 immunocompetent patients. The sensitivity, specificity, and positive and negative predictive values of the test for the diagnosis of invasive candidiasis were 81.0, 83.9, 79.1, and 85.5%, respectively.

* Corresponding author. Mailing address: Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Apartado 699, E-48080 Bilbao, Vizcaya, Spain. Phone: 34 94-6012855. Fax: 34 94-6013495. E-mail: jose.ponton{at}ehu.es.

{triangledown} Published ahead of print on 17 January 2007.

Clinical and Vaccine Immunology, March 2007, p. 318-319, Vol. 14, No. 3
1071-412X/07/$08.00+0     doi:10.1128/CVI.00396-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Clancy, C. J., Nguyen, M.-L., Cheng, S., Huang, H., Fan, G., Jaber, R. A., Wingard, J. R., Cline, C., Nguyen, M. H. (2008). Immunoglobulin G Responses to a Panel of Candida albicans Antigens as Accurate and Early Markers for the Presence of Systemic Candidiasis. J. Clin. Microbiol. 46: 1647-1654 [Abstract] [Full Text]  


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