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Clinical and Vaccine Immunology, December 2007, p. 1634-1639, Vol. 14, No. 12
1071-412X/07/$08.00+0     doi:10.1128/CVI.00339-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Enhancement of Serological Immune Responses to Foot-and-Mouth Disease Vaccine by a Supplement Made of Extract of Cochinchina Momordica Seeds{triangledown}

Chenwen Xiao,1 Zahid Iqbal Rajput,1 Diwen Liu,2 and Songhua Hu1*

Department of Veterinary Medicine, College of Animal Sciences,1 Experimental Animal Centre, Zhejiang University, Hangzhou 310029, China2

Received 16 August 2007/ Returned for modification 25 September 2007/ Accepted 11 October 2007

Foot-and-mouth disease (FMD) is a highly contagious disease affecting cloven-hoofed animals. Vaccination against FMD is a routine practice in many countries where the disease is endemic. This study was designed first to investigate the extract of the seeds of Momordica cochinchinensis (Lour.) Spreng. (ECMS) for its adjuvant effect on vaccination of inactivated FMDV antigens in a guinea pig model and then to evaluate the supplement of ECMS in oil-emulsified FMD vaccines for its immunopotentiation in pigs. The results indicated that ECMS and oil emulsion act synergistically as adjuvants to promote the production of FMDV- and VP1-specific immunoglobulin G (IgG) and subclasses in guinea pigs. A supplement of ECMS in a commercial FMD vaccine significantly enhanced FMDV-specific indirect hemagglutination assay titers as well as VP1-specific IgG and subclasses in pigs. Therefore, ECMS could be an alternative approach to improving swine FMD vaccination when the vaccine is poor to induce an effective immune response.

* Corresponding author. Mailing address: Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310029, China. Phone: 0086 571 86971852. Fax: 0086 571 86971491. E-mail: Songhua{at}zju.edu.cn

{triangledown} Published ahead of print on 17 October 2007.

Clinical and Vaccine Immunology, December 2007, p. 1634-1639, Vol. 14, No. 12
1071-412X/07/$08.00+0     doi:10.1128/CVI.00339-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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