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Clinical and Vaccine Immunology, November 2007, p. 1522-1525, Vol. 14, No. 11
1071-412X/07/$08.00+0     doi:10.1128/CVI.00144-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Dried Blood Spots versus Sera for Detection of Rubella Virus-Specific Immunoglobulin M (IgM) and IgG in Samples Collected during a Rubella Outbreak in Peru{triangledown}

Rita F. Helfand,1* Cesar Cabezas,2 Emily Abernathy,1 Carlos Castillo-Solorzano,3 Ana Cecilia Ortiz,2 Hong Sun,1 Fernando Osores,2 Lucia Oliveira,3 Alvaro Whittembury,4 Myrna Charles,1 Jon Andrus,3 and Joe Icenogle1

Centers for Disease Control and Prevention (CDC), Atlanta, Georgia,1 Instituto Nacional de Perú (INS), Ministerio de Salud, Lima, Peru,2 Pan American Health Organization, Washington, D.C,3 Dirección General de Epidemiología, Ministerio de Salud, Lima, Peru4

Received 23 March 2007/ Returned for modification 4 June 2007/ Accepted 10 September 2007

Most persons with rubella virus-specific immunoglobulin M (IgM)- or IgG-positive sera tested positive (98% [n = 178] and 99% [n = 221], respectively) using paired filter paper dried blood spot (DBS) samples, provided that DBS indeterminate results were called positive. For persons with IgM- or IgG-negative sera, 97% and 98%, respectively, were negative using DBS.

* Corresponding author. Mailing address: Centers for Disease Control and Prevention, 1600 Clifton Rd., NE, Mailstop C-12, Atlanta, GA 30333. Phone: (404) 639-3788. Fax: (404) 639-3039. E-mail: rzh7{at}cdc.gov

{triangledown} Published ahead of print on 19 September 2007.

Clinical and Vaccine Immunology, November 2007, p. 1522-1525, Vol. 14, No. 11
1071-412X/07/$08.00+0     doi:10.1128/CVI.00144-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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