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Clinical and Vaccine Immunology, October 2007, p. 1377-1380, Vol. 14, No. 10
1071-412X/07/$08.00+0     doi:10.1128/CVI.00175-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Toll-Like Receptor 4 Polymorphism Associated with the Response to Whole-Cell Pertussis Vaccination in Children from the KOALA Study{triangledown}

Sander Banus,1,2 Renske W. B. Bottema,4 Christine L. E. Siezen,2 Rob J. Vandebriel,2 Johan Reimerink,3 Monique Mommers,5,6 Gerard H. Koppelman,7 Barbara Hoebee,2 Carel Thijs,5,6 Dirkje S. Postma,4 Tjeerd G. Kimman,1* and Foekje F. Stelma8

Laboratory of Vaccine-Preventable Diseases,1 Laboratory of Toxicology, Pathology, and Genetics,2 Diagnostic Laboratory for Infectious Diseases, National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands,3 Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands,4 Department of Epidemiology, Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands,5 Nutrition and Toxicology Research Institute, Maastricht, The Netherlands,6 Department of Pediatric Pulmonology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands,7 Department of Medical Microbiology, University Hospital of Maastricht, Maastricht University, Maastricht, The Netherlands8

Received 25 April 2007/ Returned for modification 2 July 2007/ Accepted 9 August 2007

We examined the association between haplotype tagging single-nucleotide polymorphisms in TLR4 and the pertussis toxin-specific immunoglobulin G response after whole-cell pertussis (wP) vaccination in 515 1-year-old children from the KOALA study. A lower titer was associated with the minor allele of rs2770150, supporting a role for Toll-like receptor 4 in the antibody response to wP vaccination.

* Corresponding author. Mailing address: Laboratory of Vaccine-Preventable Diseases, National Institute of Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands. Phone: 31 30 2742330. Fax: 31 30 2744449. E-mail: TG.Kimman{at}rivm.nl

{triangledown} Published ahead of print on 15 August 2007.

Clinical and Vaccine Immunology, October 2007, p. 1377-1380, Vol. 14, No. 10
1071-412X/07/$08.00+0     doi:10.1128/CVI.00175-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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