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Clinical and Vaccine Immunology, October 2007, p. 1372-1376, Vol. 14, No. 10
1071-412X/07/$08.00+0     doi:10.1128/CVI.00202-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Monoclonal Antibody to Fungal Glucosylceramide Protects Mice against Lethal Cryptococcus neoformans Infection{triangledown}

Marcio L. Rodrigues,1* Li Shi,2 Eliana Barreto-Bergter,1 Leonardo Nimrichter,1 Sandra E. Farias,4 Elaine G. Rodrigues,5 Luiz R. Travassos,5 and Joshua D. Nosanchuk2,3

Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil,1 Division of Infectious Diseases, Department of Medicine,2 Department of Microbiology/Immunology, Albert Einstein College of Medicine, Bronx, New York 10461,3 Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil,4 Disciplina de Biologia Celular, Universidade Federal de São Paulo, São Paulo SP 04023-062, Brazil5

Received 17 May 2007/ Returned for modification 18 June 2007/ Accepted 13 August 2007

Glucosylceramides (GlcCer) are involved in the regulation of Cryptococcus neoformans virulence. In the present study, we demonstrate that passive immunization with a monoclonal antibody to GlcCer significantly reduces host inflammation and prolongs the survival of mice lethally infected with C. neoformans, revealing a potential therapeutic strategy to control cryptococcosis.

* Corresponding author. Mailing address: Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, 21941-590, Brazil. Phone: 55 21 2562 6740. Fax: 55 21 25608344. E-mail: marcio{at}micro.ufrj.br

{triangledown} Published ahead of print on 22 August 2007.

Clinical and Vaccine Immunology, October 2007, p. 1372-1376, Vol. 14, No. 10
1071-412X/07/$08.00+0     doi:10.1128/CVI.00202-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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