This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barbosa, F. M.
Right arrow Articles by Rodrigues, M. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barbosa, F. M.
Right arrow Articles by Rodrigues, M. L.

 Previous Article  |  Next Article 

Clinical and Vaccine Immunology, January 2007, p. 94-98, Vol. 14, No. 1
1071-412X/07/$08.00+0     doi:10.1128/CVI.00296-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Binding of Glucuronoxylomannan to the CD14 Receptor in Human A549 Alveolar Cells Induces Interleukin-8 Production{triangledown}

Fabiane M. Barbosa,1 Fernanda L. Fonseca,1 Rodrigo T. Figueiredo,2 Marcelo T. Bozza,2 Arturo Casadevall,3,4 Leonardo Nimrichter,1,{dagger} and Marcio L. Rodrigues1,{dagger}*

Laboratório de Estudos Integrados em Bioquímica Microbiana, Departamento de Microbiologia Geral,1 Departamento de Imunologia, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, 21941590 Rio de Janeiro, Brazil,2 Department of Microbiology and Immunology,3 Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, New York 104614

Received 23 August 2006/ Returned for modification 12 October 2006/ Accepted 27 October 2006

Glucuronoxylomannan (GXM) is the major capsular polysaccharide of Cryptococcus neoformans. GXM receptors have been characterized in phagocytes and endothelial cells, but epithelial molecules recognizing the polysaccharide remain unknown. In the current study, we demonstrate that GXM binds to the CD14 receptor in human type II alveolar epithelial cells, resulting in the production of the proinflammatory chemokine interleukin-8.

* Corresponding author. Mailing address: Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude (CCS), bloco I, 21941590 Rio de Janeiro, Brazil. Phone: 55 21 2562 6740. Fax: 55 21 2560 8344. E-mail: marcio{at}micro.ufrj.br.

{triangledown} Published ahead of print on 8 November 2006.

{dagger} L.N. and M.L.R. share senior authorship on this article.

Clinical and Vaccine Immunology, January 2007, p. 94-98, Vol. 14, No. 1
1071-412X/07/$08.00+0     doi:10.1128/CVI.00296-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»