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 Previous Article

Clinical and Vaccine Immunology, August 2006, p. 972-974, Vol. 13, No. 8
1071-412X/06/$08.00+0     doi:10.1128/CVI.00396-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Reduced Expression of Toll-Like Receptor 2 on Peripheral Monocytes in Patients with Chronic Hepatitis B

Stephen M. Riordan,1* Narelle Skinner,2 Jelica Kurtovic,1 Stephen Locarnini,3 and Kumar Visvanathan2

Gastrointestinal and Liver Unit, Prince of Wales Hospital and University of New South Wales, Sydney, Australia,1 Department of Infectious Diseases, Monash Medical Centre and Department of Medicine, Monash University, Melbourne, Australia,2 Victorian Infectious Diseases Reference Laboratory and University of Melbourne, Melbourne, Australia3

Received 18 November 2005/ Returned for modification 5 February 2006/ Accepted 24 May 2006

Persistent infection with hepatitis B virus (HBV) likely depends on viral inhibition of host defenses. We report that chronic hepatitis B e antigen-positive HBV infection is associated with a significant reduction in peripheral blood monocyte expression of Toll-like receptor 2, a key component of innate immunity, thereby providing a mechanism by which wild-type HBV may establish persistent infection.

* Corresponding author. Mailing address: Gastrointestinal and Liver Unit, Prince of Wales Hospital, Barker Street, Randwick 2031, New South Wales, Australia. Phone: 61 2 9382 2753. Fax: 61 2 9663 3328. E-mail: sriordan{at}ozemail.com.au.

Clinical and Vaccine Immunology, August 2006, p. 972-974, Vol. 13, No. 8
1071-412X/06/$08.00+0     doi:10.1128/CVI.00396-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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