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Clinical and Vaccine Immunology, July 2006, p. 806-809, Vol. 13, No. 7
1071-412X/06/$08.00+0     doi:10.1128/CVI.00092-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Innate Immune Response to Anaplasma phagocytophilum Contributes to Hepatic Injury

Diana G. Scorpio,1* Friederike D. von Loewenich,3 Heike Göbel,4 Christian Bogdan,3 and J. Stephen Dumler2

Department of Molecular and Comparative Pathobiology,1 Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland,2 Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany,3 Department of Pathology, University of Freiburg, Freiburg, Germany4

Received 8 March 2006/ Returned for modification 14 April 2006/ Accepted 5 May 2006

In mice, Anaplasma phagocytophilum control is independent of phagocyte oxidase (phox), inducible NO synthase (NOS2), tumor necrosis factor (TNF), and MyD88 Toll-like receptor signaling. We show that despite evasion of these host responses, phox, NOS2, TNF, and MyD88 are activated and contribute to inflammation and hepatic injury more than A. phagocytophilum itself.

* Corresponding author. Mailing address: The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, 720 Rutland Avenue, Ross 459, Baltimore, MD 21205. Phone: (410) 955-3273. Fax: (410) 502-5068. E-mail: dscorpio{at}jhmi.edu.

Clinical and Vaccine Immunology, July 2006, p. 806-809, Vol. 13, No. 7
1071-412X/06/$08.00+0     doi:10.1128/CVI.00092-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Choi, K.-S., Dumler, J. S. (2007). Mitogenic Component in Polar Lipid-Enriched Anaplasma phagocytophilum Membranes. CVI 14: 1260-1265 [Abstract] [Full Text]  
  • Choi, K.-S., Webb, T., Oelke, M., Scorpio, D. G., Dumler, J. S. (2007). Differential Innate Immune Cell Activation and Proinflammatory Response in Anaplasma phagocytophilum Infection. Infect. Immun. 75: 3124-3130 [Abstract] [Full Text]  


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