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 Previous Article

Clinical and Vaccine Immunology, June 2006, p. 711-714, Vol. 13, No. 6
1071-412X/06/$08.00+0     doi:10.1128/CVI.00031-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

West Nile and St. Louis Encephalitis Virus Antibody Seroconversion, Prevalence, and Persistence in Naturally Infected Pig-Tailed Macaques (Macaca nemestrina)

Renee R. Hukkanen,1,2* H. Denny Liggitt,1,2 Stephen T. Kelley,2 Richard Grant,2,{dagger} David M. Anderson,1,2 Roy A. Hall,3 Robert B. Tesh,4 Amelia P. Travassos DaRosa,4 and Helle Bielefeldt-Ohmann2,{ddagger}

Department of Comparative Medicine, Box 357190,1 Washington National Primate Research Center, Box 357330, University of Washington School of Medicine, Seattle, Washington 98195-7330,2 School of Molecular and Microbial Science, University of Queensland, St. Lucia, Queensland 4078, Australia,3 University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 775554

Received 26 January 2006/ Returned for modification 6 March 2006/ Accepted 23 March 2006

Pig-tailed macaques (Macaca nemestrina) naturally infected with West Nile virus were monitored from 1999 to 2005 to determine virus-specific antibody seroconversion, prevalence, and persistence. Antibodies persisted for up to 36 months, as detected by epitope-blocking enzyme-linked immunosorbent and hemagglutination inhibition assays. Exposure to cocirculating St. Louis encephalitis virus was evaluated by Western blotting and immunofluorescence assays.

* Corresponding author. Mailing address: National Primate Research Center, HSB I-421, Box 357330, Seattle, WA 98195-7330. Phone: (206) 616-1708. Fax: (206) 616-1710. E-mail: rgamboa{at}u.washington.edu.

{dagger} Present address: SNBL USA, Ltd., 6605 Merrill Creek Parkway, Everett, WA 98203.

{ddagger} Present address: Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523-1619.

Clinical and Vaccine Immunology, June 2006, p. 711-714, Vol. 13, No. 6
1071-412X/06/$08.00+0     doi:10.1128/CVI.00031-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Docherty, D. E., Samuel, M. D., Egstad, K. F., Griffin, K. M., Nolden, C. A., Karwal, L., Ip, H. S. (2009). Changes in West Nile Virus Seroprevalence and Antibody Titers among Wisconsin Mesopredators 2003-2006. Am J Trop Med Hyg 81: 177-179 [Abstract] [Full Text]  


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