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Clinical and Vaccine Immunology, March 2006, p. 423-425, Vol. 13, No. 3
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.3.423-425.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Nucleotide Oligomerization Domain 2 (Nod2) Is Not Involved in the Pattern Recognition of Candida albicans

Chantal A. A. van der Graaf,1,3 Mihai G. Netea,1,3 Barbara Franke,2 Stephen E. Girardin,4 Jos W. M. van der Meer,1,3 and Bart Jan Kullberg1,3*

Departments of Medicine,1 Human Genetics, Radboud University Nijmegen Medical Center,2 Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands,3 Unité de Pathogénie Microbienne Moleculaire, Institut Pasteur, Paris, France4

Received 10 September 2005/ Returned for modification 18 October 2005/ Accepted 20 December 2005

Nucleotide-binding oligomerization domain 2 (Nod2) pathways are known to interact with Toll-like receptor 2 (TLR2) and TLR4, which are pattern recognition receptors for Candida albicans. We observed that the prevalence of Nod2 polymorphisms was not increased in patients with Candida infections. Candida-induced cytokine production in individuals with Nod2 polymorphisms was unaffected. We conclude that Nod2 is unlikely to play an important role in the recognition of Candida albicans.

* Corresponding author. Mailing address: Department of Medicine (463), Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: 31(24)3668015. Fax: 31(24)3541734. E-mail: B.Kullberg{at}aig.umcn.nl.

Clinical and Vaccine Immunology, March 2006, p. 423-425, Vol. 13, No. 3
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.3.423-425.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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