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Clinical and Vaccine Immunology, February 2006, p. 297-300, Vol. 13, No. 2
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.2.297-300.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Development of Specific Immunoglobulin Ga (IgGa) and IgGb Antibodies Correlates with Control of Parasitemia in Babesia equi Infection

Cristina W. Cunha,1,2* Travis C. McGuire,1 Lowell S. Kappmeyer,3 Stephen A. Hines,1 A. Marianela Lopez,1 Odir A. Dellagostin,2 and Donald P. Knowles1,3

Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164-7040,1 Center for Biotechnology, Federal University of Pelotas, RS, Brazil 99010-900,2 Animal Disease Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Pullman, Washington 99164-66303

Received 8 September 2005/ Returned for modification 13 October 2005/ Accepted 12 December 2005

In this study, the kinetics of specific immunoglobulin G (IgG) isotypes were characterized in Babesia equi (Theileria equi)-infected horses. IgGa and IgGb developed during acute infection, whereas IgG(T) was detected only after resolution of acute parasitemia. The same IgG isotype profile induced during acute infection was obtained by equi merozoite antigen 1/saponin immunization.


* Corresponding author. Mailing address: Washington State University, Department of Veterinary Microbiology and Pathology, Pullman, WA 99164-7040. Phone: (509) 335-6317. Fax: (509) 335-8328. E-mail: cwcunha{at}vetmed.wsu.edu.


Clinical and Vaccine Immunology, February 2006, p. 297-300, Vol. 13, No. 2
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.2.297-300.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.




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