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Clinical and Vaccine Immunology, November 2006, p. 1291-1293, Vol. 13, No. 11
1071-412X/06/$08.00+0     doi:10.1128/CVI.00158-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Mycobacterium tuberculosis Malate Synthase- and MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis

Jacqueline M. Achkar,1,2* Yuxin Dong,1 Robert S. Holzman,1 John Belisle,3 Irene S. Kourbeti,1,{dagger} Tsering Sherpa,1 Rany Condos,1 William N. Rom,1 and Suman Laal1,2

New York University School of Medicine, New York, New York 10016,1 Department of Veterans Affairs New York Harbor Health Care System, New York, New York 10010,2 Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 805233

Received 27 April 2006/ Returned for modification 13 June 2006/ Accepted 1 August 2006

The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) of Mycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from ~80% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.

* Corresponding author. Mailing address: Department of Medicine, Albert Einstein College of Medicine, Mazer 209, 1300 Morris Park Avenue, Bronx, NY 10461. Phone: (718) 430-8763. Fax: (718) 430-8767. E-mail: jachkar{at}aecom.yu.edu.

{dagger} Present address: Department of Medicine, University Hospital of Crete, Crete, Greece.

Clinical and Vaccine Immunology, November 2006, p. 1291-1293, Vol. 13, No. 11
1071-412X/06/$08.00+0     doi:10.1128/CVI.00158-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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