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Clinical and Vaccine Immunology, November 2006, p. 1291-1293, Vol. 13, No. 11
1071-412X/06/$08.00+0     doi:10.1128/CVI.00158-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Mycobacterium tuberculosis Malate Synthase- and MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis

Jacqueline M. Achkar,^1,2* Yuxin Dong,¹ Robert S. Holzman,¹ John Belisle,³ Irene S. Kourbeti,^1, Tsering Sherpa,¹ Rany Condos,¹ William N. Rom,¹ and Suman Laal^1,2

New York University School of Medicine, New York, New York 10016,¹ Department of Veterans Affairs New York Harbor Health Care System, New York, New York 10010,² Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523³

Received 27 April 2006/ Returned for modification 13 June 2006/ Accepted 1 August 2006

The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) of Mycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from 80% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.

Present address: Department of Medicine, University Hospital of Crete, Crete, Greece.