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 Previous Article

Clinical and Vaccine Immunology, October 2006, p. 1177-1179, Vol. 13, No. 10
1071-412X/06/$08.00+0     doi:10.1128/CVI.00257-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Serum Antibodies to Pneumococcal Neuraminidase NanA in Relation to Pneumococcal Carriage and Acute Otitis Media{triangledown}

Birgit Simell,1* Teija Jaakkola,1 Mika Lahdenkari,1 David Briles,2 Susan Hollingshead,2 Terhi M. Kilpi,1 and Helena Käyhty1

National Public Health Institute, Helsinki, Finland,1 University of Alabama, Birmingham, Alabama2

Received 13 July 2006/ Accepted 12 August 2006

Pneumococcal neuraminidase, NanA, is a pneumococcal vaccine candidate. Prior culture-confirmed pneumococcal contacts were shown to induce serum anti-NanA antibodies during the first 2 years of life. The antibody concentrations at neither 12 nor 18 months were significantly associated with the risk of subsequent pneumococcal carriage or acute otitis media.

* Corresponding author. Mailing address: Vaccine Immunology Laboratory, National Public Health Institute, Mannerheimintie 166, 0300 Helsinki, Finland. Phone: 358-9-4744 8901. Fax: 358-9-4744 8599. E-mail: birgit.simell{at}ktl.fi.

{triangledown} Published ahead of print on 23 August 2006.

Clinical and Vaccine Immunology, October 2006, p. 1177-1179, Vol. 13, No. 10
1071-412X/06/$08.00+0     doi:10.1128/CVI.00257-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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