This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Philipp, M. T.
Right arrow Articles by Martin, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Philipp, M. T.
Right arrow Articles by Martin, D.

 Previous Article  |  Next Article 

Clinical and Vaccine Immunology, October 2006, p. 1170-1171, Vol. 13, No. 10
1071-412X/06/$08.00+0     doi:10.1128/CVI.00238-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Serologic Evaluation of Patients from Missouri with Erythema Migrans-Like Skin Lesions with the C6 Lyme Test

Mario T. Philipp,1* Edwin Masters,2 Gary P. Wormser,3 Wayne Hogrefe,4 and Dale Martin1

Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana,1 Family Practice of Dr. Edwin Masters, Cape Girardeau, Missouri,2 Division of Infectious Diseases, Department of Medicine of New York Medical College, Valhalla, New York,3 Focus Diagnostics, Inc., Cypress, California4

Received 26 June 2006/ Accepted 27 July 2006

Southern tick-associated rash illness (STARI), also known as Masters disease, affects people predominantly in the Southeast and South Central United States. These patients exhibit skin lesions that resemble erythema migrans (EM), the characteristic skin lesion in early Lyme disease. The etiology of STARI remains unknown, and no serologic test is available to aid in its diagnosis. The C6 Lyme enzyme-linked immunosorbent assay was used to evaluate coded serum specimens from patients with STARI at two laboratory sites. The specimens tested at one site consisted of acute- and convalescent-phase samples that were obtained from nine STARI patients from Missouri and from one patient with documented Borrelia lonestari infection who acquired this infection in either North Carolina or Maryland. All of these samples were C6 negative. Seventy acute- or convalescent-phase specimens from 63 STARI patients from Missouri were C6 tested at the second site. All but one of these STARI specimens were also negative. In contrast, of nine acute- and nine convalescent-phase serum specimens obtained from culture-confirmed Lyme disease patients with EM from New York state, seven were C6 positive at the acute stage, and eight were positive at convalescence. The C6 test is negative in patients with STARI, providing further evidence that B. burgdorferi is not the etiologic agent of this disease.

* Corresponding author. Mailing address: Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433. Phone: (985) 871-6221. Fax: (985) 871-6390. E-mail: Philipp{at}tpc.tulane.edu.

Clinical and Vaccine Immunology, October 2006, p. 1170-1171, Vol. 13, No. 10
1071-412X/06/$08.00+0     doi:10.1128/CVI.00238-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gomes-Solecki, M. J. C., Meirelles, L., Glass, J., Dattwyler, R. J. (2007). Epitope Length, Genospecies Dependency, and Serum Panel Effect in the IR6 Enzyme-Linked Immunosorbent Assay for Detection of Antibodies to Borrelia burgdorferi. CVI 14: 875-879 [Abstract] [Full Text]  
  • Tibbles, C. D., Edlow, J. A. (2007). Does This Patient Have Erythema Migrans?. JAMA 297: 2617-2627 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»