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Clinical and Vaccine Immunology, January 2006, p. 160-161, Vol. 13, No. 1
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.1.160-161.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Can the Level of Immunosuppression in Human Immunodeficiency Virus-Infected Patients Affect the Reliability of Human T-Cell Lymphotropic Virus Type 2 Serological Diagnosis?

Sylvina Bassani, Carlos Toro,* Victoria Jiménez, Berta Rodés, and Vincent Soriano

Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain

Received 14 July 2005/ Returned for modification 20 September 2005/ Accepted 21 October 2005

A total of 175 human immunodeficiency virus (HIV)-positive intravenous drug users (IDU) with CD4 cell counts of <200 cells/µl were matched with 175 HIV-positive IDU with CD4 cell counts of >500 cells/µl. Enzyme immunoassay (EIA) reactivity and human T-cell lymphotropic virus type 2 (HTLV-2) Western blot (WB) positivity were more frequently observed in subjects with CD4 cell counts of >500 cells/µl. Most of the subjects with low CD4 cell counts and EIA reactivity carried HTLV-2 infection (WB positive and/or PCR positive). No subjects with low CD4 cell counts and a lack of reactive EIA were PCR positive for HTLV-2. Therefore, a negative EIA result can confidently discharge HTLV-2 infection in HIV-infected patients with severe immunosuppression, whereas PCR should be performed for subjects with a reactive HTLV EIA which is not further confirmed by WB.

* Corresponding author. Mailing address: Department of Infectious Diseases, Hospital Carlos III, Calle Sinesio Delgado 10, 28029 Madrid, Spain. Phone: 34 91 4532500. Fax: 34 91 7336614. E-mail: carlostororueda{at}hotmail.com.

Clinical and Vaccine Immunology, January 2006, p. 160-161, Vol. 13, No. 1
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.1.160-161.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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