This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zanetti, S.
Right arrow Articles by Fadda, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zanetti, S.
Right arrow Articles by Fadda, G.

 Previous Article  |  Next Article 

Clinical and Diagnostic Laboratory Immunology, September 2005, p. 1135-1138, Vol. 12, No. 9
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.9.1135-1138.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Patients with Pulmonary Tuberculosis Develop a Strong Humoral Response against Methylated Heparin-Binding Hemagglutinin

Stefania Zanetti,1 Alessandra Bua,1 Giovanni Delogu,1,6 Cinzia Pusceddu,1,6 Maristella Mura,2 Franca Saba,2 Piero Pirina,3 Carlo Garzelli,4 Cono Vertuccio,5 Leonardo A. Sechi,1* and Giovanni Fadda6

Department of Biomedical Sciences,1 Institute of Infectious Diseases,2 Institute of Respiratory Diseases, University of Sassari, Sassari, Italy,3 Department of Experimental Pathology and Biotechnology, University of Pisa, Pisa, Italy,4 Institute of Tisiology, Azienda Sanitaria Locale no. 3 of Nuoro, Nuoro, Italy,5 Institute of Microbiology, Catholic University, Rome, Italy6

Received 17 May 2005/ Returned for modification 31 May 2005/ Accepted 13 July 2005

Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.

* Corresponding author. Mailing address: Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy. Phone: 39 079 228463. Fax: 39 079 212345. E-mail: sechila{at}uniss.it.

Clinical and Diagnostic Laboratory Immunology, September 2005, p. 1135-1138, Vol. 12, No. 9
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.9.1135-1138.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Shin, A-R., Lee, K.-S., Lee, J.-S., Kim, S.-Y., Song, C.-H., Jung, S.-B., Yang, C.-S., Jo, E.-K., Park, J.-K., Paik, T.-H., Kim, H.-J. (2006). Mycobacterium tuberculosis HBHA Protein Reacts Strongly with the Serum Immunoglobulin M of Tuberculosis Patients. CVI 13: 869-875 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»