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Clinical and Diagnostic Laboratory Immunology, September 2005, p. 1135-1138, Vol. 12, No. 9
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.9.1135-1138.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Patients with Pulmonary Tuberculosis Develop a Strong Humoral Response against Methylated Heparin-Binding Hemagglutinin

Stefania Zanetti,1 Alessandra Bua,1 Giovanni Delogu,1,6 Cinzia Pusceddu,1,6 Maristella Mura,2 Franca Saba,2 Piero Pirina,3 Carlo Garzelli,4 Cono Vertuccio,5 Leonardo A. Sechi,1* and Giovanni Fadda6

Department of Biomedical Sciences,1 Institute of Infectious Diseases,2 Institute of Respiratory Diseases, University of Sassari, Sassari, Italy,3 Department of Experimental Pathology and Biotechnology, University of Pisa, Pisa, Italy,4 Institute of Tisiology, Azienda Sanitaria Locale no. 3 of Nuoro, Nuoro, Italy,5 Institute of Microbiology, Catholic University, Rome, Italy6

Received 17 May 2005/ Returned for modification 31 May 2005/ Accepted 13 July 2005

Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.

* Corresponding author. Mailing address: Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy. Phone: 39 079 228463. Fax: 39 079 212345. E-mail: sechila{at}uniss.it.

Clinical and Diagnostic Laboratory Immunology, September 2005, p. 1135-1138, Vol. 12, No. 9
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.9.1135-1138.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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Copyright © 2005 by the American Society for Microbiology. All rights reserved.