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Clinical and Diagnostic Laboratory Immunology, September 2005, p. 1119-1122, Vol. 12, No. 9
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.9.1119-1122.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Endogenous Superantigens Shape Response to Exogenous Superantigens

Govindarajan Rajagopalan,1 Manisha Singh,1 Moon M. Sen,1 Narayana S. Murali,2 Karl A. Nath,2 and Chella S. David1*

Department of Immunology,1 Division of Nephrology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota2

Received 23 February 2005/ Returned for modification 26 April 2005/ Accepted 28 June 2005

Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vß8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vß8+ T cells, was significantly reduced and conferred protection from superantigen-induced mortality.

* Corresponding author. Mailing address: Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905. Phone: (507) 284-8180. Fax: (507) 266-0981. E-mail: david.chella{at}mayo.edu.

Clinical and Diagnostic Laboratory Immunology, September 2005, p. 1119-1122, Vol. 12, No. 9
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.9.1119-1122.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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