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Clinical and Diagnostic Laboratory Immunology, August 2005, p. 1003-1005, Vol. 12, No. 8
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.8.1003-1005.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Patterns of CD8 T-Cell Epitopes within the Human Papillomavirus Type 16 (HPV 16) E6 Protein among Young Women Whose HPV 16 Infection Has Become Undetectable

Mayumi Nakagawa,1,2,3* Kevin H. Kim,1 and Anna-Barbara Moscicki4

Departments of Dermatology,1 Pathology,2 Microbiology and ImmunologyUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas 72205,3 Department of Pediatrics, Schools of Medicine, University of California at San Francisco, San Francisco, California 941434

Received 25 January 2005/ Returned for modification 11 March 2005/ Accepted 27 April 2005

The patterns of CD8 T-cell epitopes recognized within the E6 protein in women who had cleared their human papillomavirus 16 infection were examined. T-cell lines were established using autologous dendritic cells infected with a recombinant vaccinia virus. Evidence of potential antigenic epitopes was shown in 8 of 23 (34.8%) women.

* Corresponding author. Mailing address: 4301 West Markham, Slot #576, Little Rock, AR 72205. Phone: (501) 686-8635. Fax: (501) 686-7264. E-mail: mnakagawa{at}uams.edu.

Clinical and Diagnostic Laboratory Immunology, August 2005, p. 1003-1005, Vol. 12, No. 8
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.8.1003-1005.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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