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Clinical and Diagnostic Laboratory Immunology, May 2005, p. 668-670, Vol. 12, No. 5
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.5.668-670.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Evaluation of Commercial Assay Detecting Specific Immunoglobulin G in Oral Fluid for Determining Measles Immunity in Vaccinees

Jacques R. Kremer and Claude P. Muller*

Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, L-1011 Luxembourg

Received 16 December 2004/ Returned for modification 14 January 2005/ Accepted 23 February 2005

A commercial assay for detection of measles immunoglobulin G (IgG) in oral fluid was evaluated in a highly vaccinated cohort using serum IgG as gold standard. In contrast to previous studies from cohorts protected by natural immunity, antibody prevalence was significantly underestimated (–7.4%; confidence interval: –1.5 to –13.2%; P = 0.01) due to a reduced sensitivity when antibody levels were low.

* Corresponding author. Mailing address: Institute of Immunology, Laboratoire National de Santé, 20A, rue Auguste Lumière, L-1011 Luxembourg. Phone: 352-490604. Fax: 352-490686. E-mail: claude.muller{at}LNS.ETAT.LU.

Clinical and Diagnostic Laboratory Immunology, May 2005, p. 668-670, Vol. 12, No. 5
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.5.668-670.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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