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Retrospective Serological Investigation of Severe Acute Respiratory Syndrome Coronavirus Antibodies in Recruits from Mainland China

Sumeng Yu,^1, Maofeng Qiu,^2, Zeliang Chen,^2, Xiaobo Ye,¹ Yaling Gao,¹ Aimin Wei,¹ Xiaoyi Wang,² Ling Yang,³ Jin Wang,² Jie Wen,³ Yajun Song,² Decui Pei,² Erhei Dai,² Zhaobiao Guo,² Cheng Cao,⁴ Jian Wang,³ and Ruifu Yang^2*

Infectious Disease Control Unit, Logistic Department for Air Forces, Beijing Military Area,¹ Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences,² Beijing Genomics Institute, Chinese Academy of Sciences,³ Beijing Institute of Bioengineering, Beijing, People's Republic of China⁴

Received 19 October 2004/ Returned for modification 3 January 2005/ Accepted 19 January 2005

Different assays were used to analyze 1,621 serum specimens collected from military recruits from the People's Republic of China in 2002 for severe acute respiratory syndrome (SARS) coronavirus antibodies. The results demonstrated that the subjects either had rarely been exposed to the virus before the 2003 SARS outbreak or had not been exposed but the nucleocapsid protein cross-reacted with other antibodies in humans.

S.Y., M.Q., and Z.C. contributed equally to this work.