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Use of the COOH Portion of the Nucleocapsid Protein in an Antigen-Capturing Enzyme-Linked Immunosorbent Assay for Specific and Sensitive Detection of Severe Acute Respiratory Syndrome Coronavirus

Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences,¹ PLA General Hospital,² Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, People's Republic of China³

Received 26 November 2004/ Returned for modification 28 December 2004/ Accepted 5 January 2005

Antibody detection with a recombinant COOH portion of the severe acute respiratory syndrome (SARS) coronavirus nucleocapsid (N) protein, N13 (amino acids 221 to 422), was demonstrated to be more specific and sensitive than that with the full-length N protein, and an N13-based antigen-capturing enzyme-linked immunosorbent assay providing a convenient and specific test for serodiagnosis and epidemiological study of SARS was developed.

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