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Clinical and Diagnostic Laboratory Immunology, December 2005, p. 1455-1457, Vol. 12, No. 12
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.12.1455-1457.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Longitudinal Analysis of Severe Acute Respiratory Syndrome (SARS) Coronavirus-Specific Antibody in SARS Patients

Shan-Chwen Chang,1* Jann-Tay Wang,1 Li-Min Huang,2 Yee-Chun Chen,1 Chi-Tai Fang,1 Wang-Huei Sheng,1 Jiun-Ling Wang,1 Chong-Jen Yu,1 and Pan-Chyr Yang1

Department of Internal Medicine,1 Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan2

Received 14 February 2005/ Returned for modification 12 April 2005/ Accepted 29 September 2005

The serum antibodies to severe acute respiratory syndrome (SARS) coronavirus of 18 SARS patients were checked at 1 month and every 3 months after disease onset. All of them except one, who missed blood sampling at 1 month, tested positive for the immunoglobulin G (IgG) antibody at 1 month. Fifteen out of 17 tested positive for the IgM antibody at 1 month. The serum IgM antibody of most patients became undetectable within 6 months after the onset of SARS. The IgG antibody of all 17 patients, whose serum was checked 1 year after disease onset, remained positive.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan. Phone: 886-2-23123456, ext. 5401. Fax: 886-2-23971412. E-mail: sc4030{at}ha.mc.ntu.edu.tw.

Clinical and Diagnostic Laboratory Immunology, December 2005, p. 1455-1457, Vol. 12, No. 12
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.12.1455-1457.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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