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Clinical and Diagnostic Laboratory Immunology, October 2005, p. 1251-1253, Vol. 12, No. 10
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.10.1251-1253.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Immunogenicity of Meningococcal ACYW135 Polysaccharide Vaccine in Saudi Children 5 to 9 Years of Age

M. Khalil,1 Y. Al-Mazrou,2 P. Balmer,3* J. Bramwell,3 N. Andrews,4 and R. Borrow3

Medical Education and Research Center, King Fahad Specialist Hospital, Qassim, Saudi Arabia,1 Department of Preventive Medicine, Ministry of Health, Riyadh, Saudi Arabia,2 Meningococcal Reference Unit, HPA North West Laboratory, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom,3 Statistics Unit, HPA Centre for Infections, London NW9 5EQ, United Kingdom4

Received 14 July 2005/ Returned for modification 9 August 2005/ Accepted 10 August 2005

Meningococcal tetravalent polysaccharide vaccines were observed to be immunogenic in Saudi children 5 to 9 years of age, with >90% having serum bactericidal antibody titers of ≥8 for serogroups A, Y, and W135; for serogroup C, 77% were putatively protected after vaccination.

* Corresponding author. Mailing address: Meningococcal Reference Unit, HPA North West Laboratory, Manchester Royal Infirmary, Manchester, M13 9WZ, United Kingdom. Phone: 44 161 276 5697. Fax: 44 161 276 6792. E-mail: paul.balmer{at}hpa.org.uk.

Clinical and Diagnostic Laboratory Immunology, October 2005, p. 1251-1253, Vol. 12, No. 10
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.10.1251-1253.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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