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Clinical and Diagnostic Laboratory Immunology, October 2005, p. 1235-1237, Vol. 12, No. 10
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.10.1235-1237.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Immunoglobulin A Antibody Responses in Dengue Patients: a Useful Marker for Serodiagnosis of Dengue Virus Infection

M. Nawa,1* T. Takasaki,2 M. Ito,2 S. Inoue,3 K. Morita,3 and I. Kurane2

Department of Microbiology, Saitama Medical School 38, Moroyama, Saitama 350-0495, Japan,1 Division of Arboviruses, Department of Virology 1, National Institute of Infectious Diseases, 1-23-1, Toyama, Sinjuku, Tokyo 162-8640, Japan,2 Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki-shi, Nagasaki 852-8523, Japan3

Received 26 April 2005/ Returned for modification 11 July 2005/ Accepted 14 August 2005

We determined the usefulness of an immunoglobulin A (IgA) antibody-capture enzyme-linked immunosorbent assay for serodiagnosis of dengue virus infections. The results indicate that the presence of IgA and IgM in serum samples assures recent primary dengue virus infection even with a single serum sample.

* Corresponding author. Mailing address: Department of Microbiology, Saitama Medical School 38, Moroyama, Saitama 350-0495, Japan. Phone and fax: 81-49-276-1438. E-mail: mnawa{at}saitama-med.ac.jp.

Clinical and Diagnostic Laboratory Immunology, October 2005, p. 1235-1237, Vol. 12, No. 10
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.10.1235-1237.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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