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Clinical and Diagnostic Laboratory Immunology, January 2005, p. 76-80, Vol. 12, No. 1
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.1.76-80.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Memory Responses in Human Immunodeficiency Virus Type 1-Infected Individuals with Long-Term Viral Load Suppression Are Independent of CD4 Cell Nadir

Michael A. Kolber,* Maria O. Saenz, and Sameer Kaul

Division of Infectious Diseases, Department of Medicine, University of Miami School of Medicine, Miami, Florida

Received 19 April 2004/ Returned for modification 21 June 2004/ Accepted 6 October 2004

The persistence of memory responses in suppressive highly active antiretroviral therapy (HAART) has been an area of controversy. By using a previously described proliferation assay that augments specific responses, peripheral blood lymphocytes (PBL) from 61 human immunodeficiency virus type 1-seropositive individuals with CD4 counts of >300/mm3 and suppressed viral burdens were studied for response to p24 antigen as a function of time of viral load suppression on HAART. In the majority of cases, proliferative responses could be measured in PBL from patients with plasma viral load suppression. No differences could be found in proliferative responses from PBL between individuals with a low and those with a high CD4 cell nadir. PBL that did not respond to either Casta antigen or p24 were found to have a higher percentage of naïve cells than did PBL that responded well to antigen. These data support the contention that, after long-term viral load suppression, PBL from infected individuals have memory cell populations that can respond to antigenic stimulation under inducible conditions.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Medicine, University of Miami School of Medicine, P.O. Box 016960 (R21), Miami, FL 33101. Phone: (305) 243-4791. Fax: (305) 243-2362. E-mail: mkolber{at}med.Miami.edu.

Clinical and Diagnostic Laboratory Immunology, January 2005, p. 76-80, Vol. 12, No. 1
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.1.76-80.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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