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Clinical and Diagnostic Laboratory Immunology, November 2004, p. 1194-1197, Vol. 11, No. 6
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.6.1194-1197.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Lack of Association between Toll-Like Receptor 2 Polymorphisms and Susceptibility to Severe Disease Caused by Staphylococcus aureus

Catrin E. Moore,1* Shelley Segal,1 Anthony R. Berendt,2 Adrian V. S. Hill,1 and Nicholas P. J. Day1,3

Nuffield Department of Clinical Medicine, John Radcliffe Hospital,1 Bone Infection Unit, Nuffield Orthopaedic Centre NHS Trust, Oxford, United Kingdom,2 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand3

Received 3 June 2004/ Returned for modification 12 August 2004/ Accepted 27 August 2004

To investigate a putative link between genetically determined variations in Toll-like receptor 2 (TLR2) and the occurrence of severe Staphylococcus aureus infection, the functional Arg753Gln single-nucleotide polymorphism and the GT repeat microsatellite in the TLR2 gene were examined in a large case-control study. No associations with disease or mortality attributable to these features were found.

* Corresponding author. Mailing address: Paediatric Infection and Immunity Laboratory, Department of Paediatrics, University of Oxford, Level 4, John Radcliffe Hospital, Oxford, OX3 9DU United Kingdom. Phone: 44 1865 221073. Fax: 44 1865 220479. E-mail: catrin.moore{at}paediatrics.ox.ac.uk.

Clinical and Diagnostic Laboratory Immunology, November 2004, p. 1194-1197, Vol. 11, No. 6
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.6.1194-1197.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Schroder, N. W. J., Diterich, I., Zinke, A., Eckert, J., Draing, C., Baehr, V. v., Hassler, D., Priem, S., Hahn, K., Michelsen, K. S., Hartung, T., Burmester, G. R., Gobel, U. B., Hermann, C., Schumann, R. R. (2005). Heterozygous Arg753Gln Polymorphism of Human TLR-2 Impairs Immune Activation by Borrelia burgdorferi and Protects from Late Stage Lyme Disease. J. Immunol. 175: 2534-2540 [Abstract] [Full Text]  
  • Fournier, B., Philpott, D. J. (2005). Recognition of Staphylococcus aureus by the Innate Immune System. Clin. Microbiol. Rev. 18: 521-540 [Abstract] [Full Text]  


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