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Clinical and Diagnostic Laboratory Immunology, September 2004, p. 930-935, Vol. 11, No. 5
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.5.930-935.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Low CD4+ T-Lymphocyte Values in Human Immunodeficiency Virus-Negative Adults in Botswana

Hermann Bussmann,1,2 C. William Wester,1,2 Kereng V. Masupu,3 Trevor Peter,1,2 Sarah M. Gaolekwe,4 Soyeon Kim,1,5 Ann Marie Reich,1,2 Sam Ahn,1,2 Ying Wu,1,2 Ibou Thior,1,5 Max Essex,1,2 and Richard Marlink1,2*

Botswana-Harvard AIDS Institute Partnership,1 National AIDS Coordinating Agency,3 National Health Laboratory, Gaborone, Botswana,4 Harvard AIDS Institute,2 Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts5

Received 30 September 2003/ Returned for modification 31 March 2004/ Accepted 1 June 2004

CD4+-lymphocyte counts (LCs) play a crucial role in the management and monitoring of HIV infection. Variability in CD4+ LCs has been reported to occur as a result of measurement techniques and/or biological variations. We report on the CD4+ LCs of healthy human immunodeficiency virus (HIV)-seronegative adults in Botswana. Samples were obtained from HIV-seronegative blood donors. The median CD4+ LC was 726 cells/mm3 (for females, 782 cells/mm3; for males, 698 cells/mm3). The median CD8+ LC was 488 cells/mm3 (for females, 494 cells/mm3; for males, 485 cells/mm3). The median CD4+-to-CD8+ ratio was 1.57 (for females, 1.66; for males, 1.51). Our findings of low CD4+ LCs among HIV-negative adults in Botswana are significant and have important implications for the management of HIV disease in the population of this sub-Saharan African country.

* Corresponding author. Mailing address: Harvard AIDS Institute, 651 Huntington Ave., Suite 631, Boston, MA 02115. Phone: (617) 432-4114. Fax: (617) 432-4545. E-mail: marlink{at}hsph.harvard.edu.

Clinical and Diagnostic Laboratory Immunology, September 2004, p. 930-935, Vol. 11, No. 5
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.5.930-935.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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