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 Previous Article

Clinical and Diagnostic Laboratory Immunology, July 2004, p. 814-817, Vol. 11, No. 4
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.4.814-817.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Evaluation of Clonorchis sinensis Recombinant 7-Kilodalton Antigen for Serodiagnosis of Clonorchiasis

Qin-Ping Zhao,1,2 Sung-Ung Moon,1 Hyeong-Woo Lee,1 Byoung-Kuk Na,3 Seung-Yull Cho,3 Yoon Kong,3 Ming-Sen Jiang,2 Ai-Hua Li,1,4 and Tong-Soo Kim1*

Department of Tropical and Endemic Parasitic Diseases, National Institute of Health, Seoul 122-701,1 Department of Molecular Parasitology and Center for Molecular Medicine, Sungkyunkwan University School of Medicine and Samsung Biomedical Research Institute, Suwon 440-746, Korea,3 Department of Parasitology, School of Medicine, Wuhan University, Wuhan 430071,2 State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China4

Received 29 January 2004/ Returned for modification 8 March 2004/ Accepted 16 March 2004

The diagnostic applicability of the Clonorchis sinensis recombinant 7-kDa protein was evaluated. In enzyme-linked immunosorbent assays and immunoblots, the protein showed high sensitivities (81.3 and 71.9%, respectively) and specificities (92.6 and 89.7%, respectively) for sera obtained from various helminthic infections. Some paragonimiasis sera showed cross-reactions. The antigen might be valuable in the serodiagnosis of human clonorchiasis.

* Corresponding author. Mailing address: Department of Tropical and Endemic Parasitic Diseases, National Institute of Health, Seoul 122-701, Korea. Phone: (82) 2 380 1505. Fax: (82) 2 380 1560. E-mail: nihkim{at}nih.go.kr.

Clinical and Diagnostic Laboratory Immunology, July 2004, p. 814-817, Vol. 11, No. 4
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.4.814-817.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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