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Clinical and Diagnostic Laboratory Immunology, July 2004, p. 808-810, Vol. 11, No. 4
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.4.808-810.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Long-Term Effects of Immunization with Recombinant Lipoprotein Outer Surface Protein A on Serologic Test for Lyme Disease

Paul T. Fawcett,1,2* Carlos D. Rose,2,3 and Victoria Maduskuie1

Immunology Laboratory, Department of Research,1 Division of Rheumatology, Department of Pediatrics, A. I. duPont Hospital for Children, Wilmington, Delaware,3 Thomas Jefferson University, Philadelphia, Pennsylvania2

Received 24 December 2003/ Returned for modification 27 January 2004/ Accepted 1 April 2004

Immunization with recombinant lipoprotein outer surface protein A vaccine is known to interfere with some serologic tests for Lyme disease. We tested sera from 152 vaccine recipients by using in-house and commercial Western blot assays and found that vaccination caused interference in up to 25% of recipients and can persist for over 6 years.

* Corresponding author. Mailing address: Immunology Laboratory, Department of Research, A. I. duPont Hospital for Children, 1600 Rockland Rd., Wilmington, DE 19803. Phone: (302) 651-6776. Fax: (302) 651-6881. E-mail: pfawcett{at}nemours.org.

Clinical and Diagnostic Laboratory Immunology, July 2004, p. 808-810, Vol. 11, No. 4
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.4.808-810.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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