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Clinical and Diagnostic Laboratory Immunology, July 2004, p. 799-800, Vol. 11, No. 4
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.4.799-800.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Evaluation of a Monoclonal Antibody-Based Test for Detection of Helicobacter pylori-Specific Antigen in Stool Samples from Mice

Julia Crone,1,{dagger} Erin Symonds,1* Fiona Campbell,1,2 and Ross Butler1,3

Gastroenterology Unit, Women's and Children's Hospital, North Adelaide, 5006 South Australia,1 Numico Research Australia Pty. Ltd., Oakden, 5086 South Australia,2 Department of Paediatrics, University of Adelaide, Adelaide, 5005 South Australia, Australia3

Received 18 December 2003/ Returned for modification 27 January 2004/ Accepted 18 March 2004

A test using monoclonal antibodies for detection of antigen in stool samples was compared with culture and histology for noninfected (n = 25), Helicobacter pylori-infected (n = 25), and Helicobacter felis-infected (n = 6) mice. Sensitivity and specificity were 96%. The monoclonal antibody-based test is therefore a noninvasive technique that is able to diagnose H. pylori infection in mice.

* Corresponding author. Mailing address: Gastroenterology Unit, Women's and Children's Hospital, 72 King William Rd., North Adelaide, 5006 South Australia, Australia. Phone: 61 8 8161 7189. Fax: 61 8 8161 6088. E-mail: erinsymonds{at}yahoo.com.

{dagger} Present address: Universitaetsklinik fuer Kinder- und Jugendheilkunde, 1090 Vienna, Austria.

Clinical and Diagnostic Laboratory Immunology, July 2004, p. 799-800, Vol. 11, No. 4
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.4.799-800.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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