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Clinical and Diagnostic Laboratory Immunology, July 2004, p. 786-788, Vol. 11, No. 4
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.4.786-788.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Comparison of Immunofluorescence, Western Blotting, and Cross-Adsorption Assays for Diagnosis of African Tick Bite Fever

Mogens Jensenius,1* Pierre-Edouard Fournier,2 Sirkka Vene,3 Signe Holta Ringertz,4 Bjørn Myrvang,5 and Didier Raoult2

Departments of Internal Medicine,1 Bacteriology, Aker University Hospital,4 Department of Infectious Diseases, Ullevål University Hospital, Oslo, Norway,5 Unité des Rickettsies, Université de la Méditerranée, Marseille, France,2 Swedish Institute for Infectious Disease Control, Solna, Sweden3

Received 10 January 2004/ Returned for modification 18 February 2004/ Accepted 30 March 2004

In testing paired serum samples from 40 consecutive cases of African tick bite fever, we detected diagnostic antibodies against spotted fever group rickettsiae in 45% of the patients by immunofluorescence assay (IFA) and in 100% of the patients by Western blotting (WB) (P < 0.01). A specific diagnosis of Rickettsia africae infection could be established in 15% of the patients by IFA and in 73% of the patients by a combination of WB and cross-adsorption assays (P < 0.01).

* Corresponding author. Mailing address: Department of Internal Medicine, Aker University Hospital, Trondheimsveien 235, NO-0514 Oslo, Norway. Phone: 47 2289 4000. Fax: 47 2289 4008. E-mail: mogens.jensenius{at}ioks.uio.no.

Clinical and Diagnostic Laboratory Immunology, July 2004, p. 786-788, Vol. 11, No. 4
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.4.786-788.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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