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Clinical and Diagnostic Laboratory Immunology, July 2004, p. 758-761, Vol. 11, No. 4
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.4.758-761.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Evolution of Vaccinia Virus-Specific CD8+ Cytotoxic T-Lymphocyte Responses in Primary Vaccinees and Revaccinees

Allan R. Tenorio,1* Mark E. Peeples,2,{dagger} Manokiran Patri,1 Katayoun Rezai,1 and Gordon M. Trenholme1

Section of Infectious Diseases, Department of Medicine,1 Department of Microbiology and Immunology, Rush Medical College, Chicago, Illinois2

Received 27 February 2004/ Returned for modification 3 April 2004/ Accepted 1 May 2004

Determination of successful vaccination with vaccinia virus is based on visual confirmation of a dermal response (take). Some revaccinees do not manifest a take, which may be due to a preexisting immunity rather than to poor technique or inadequate virus. Cytotoxic T-lymphocyte (CTL) response appears to be the most important immune defense in limiting response to vaccination. We evaluated vaccinia virus-specific CTL responses in revaccinees. Subjects with and without takes displayed comparable CTL responses. Vaccinia virus-specific CD8+ CTL responses may be useful in interpreting the response to vaccination, particularly in individuals who are revaccinated and have difficult-to-interpret visual takes.

* Section of Infectious Diseases, Department of Medicine, Rush Medical College, 600 S. Paulina St., Suite 143 AAC, Chicago, IL 60613. Phone: (312) 942-5865. Fax: (312) 942-8200. E-mail: allan_s_tenorio{at}rush.edu.

{dagger} Present address: Center for Vaccines and Immunity, Columbus Children's Research Institute, Department of Pediatrics, The Ohio State University College of Medicine and Public Health, Columbus, Ohio.

Clinical and Diagnostic Laboratory Immunology, July 2004, p. 758-761, Vol. 11, No. 4
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.4.758-761.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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Copyright © 2004 by the American Society for Microbiology. All rights reserved.