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Clinical and Diagnostic Laboratory Immunology, March 2004, p. 426-429, Vol. 11, No. 2
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.2.426-429.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Extracellular Calcium and Magnesium, but Not Iron, Are Needed for Optimal Growth of Blastomyces dermatitidis Yeast Form Cells In Vitro

Steven S. Giles and Charles J. Czuprynski*

Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin 53706

Received 9 June 2003/ Returned for modification 9 October 2003/ Accepted 20 November 2003

In the present study, we demonstrate that the yeast form of Blastomyces dermatitidis can proliferate for short periods of time in the absence of ferric iron but not in the absence of calcium or magnesium. The results of this study shed light on the resistance of B. dermatitidis to chelating agents, such as deferoxamine, and may explain how B. dermatitidis resists the iron-binding activity of serum transferrin.

* Corresponding author. Mailing address: Department of Pathobiological Sciences, 2015 Linden Dr., Madison, WI 53706. Phone and fax: (608) 262-8102. E-mail: czuprync{at}svm.vetmed.wisc.edu.

Clinical and Diagnostic Laboratory Immunology, March 2004, p. 426-429, Vol. 11, No. 2
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.2.426-429.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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