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Clinical and Diagnostic Laboratory Immunology, March 2004, p. 392-398, Vol. 11, No. 2
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.2.392-398.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

High Prevalence of Antibodies to Hepatitis A and E Viruses and Viremia of Hepatitis B, C, and D Viruses among Apparently Healthy Populations in Mongolia

Masaharu Takahashi,1 Tsutomu Nishizawa,1 Yuhko Gotanda,2 Fumio Tsuda,3 Fumio Komatsu,4 Terue Kawabata,5 Kyoko Hasegawa,6 Murdorjyn Altankhuu,7 Ulziiburen Chimedregzen,7 Luvsanbasaryn Narantuya,7 Hiromi Hoshino,8 Kunihiko Hino,8 Yasuo Kagawa,9 and Hiroaki Okamoto1*

Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi-Ken 329-0498,1 Japanese Red Cross Saitama Blood Center, Saitama-Ken 360-0806,2 Department of Medical Sciences, Toshiba General Hospital, Tokyo 140-8522,3 Division of Clinical Physiology,4 Division of Nutritional Biochemistry,6 Division of Medical Chemistry, Graduate School,9 Division of Basic Nutrition, Faculty of Nutrition,5 Kagawa Nutrition University, Saitama-Ken 350-0288, and Delta Clinic, Saitama-Ken 359-0037, Japan,8 Public Health Institute, Ministry of Health of Mongolia, Ulaanbaatar 210523, Mongolia7

Received 12 September 2003/ Accepted 13 November 2003

The prevalence of infection with hepatitis A virus (HAV), HBV, HCV, HDV, and HEV was evaluated in 249 apparently healthy individuals, including 122 inhabitants in Ulaanbaatar, the capital city of Mongolia, and 127 age- and sex-matched members of nomadic tribes who lived around the capital city. Overall, hepatitis B surface antigen (HBsAg) was detected in 24 subjects (10%), of whom 22 (92%) had detectable HBV DNA. Surprisingly, HDV RNA was detectable in 20 (83%) of the 24 HBsAg-positive subjects. HCV-associated antibodies were detected in 41 (16%) and HCV RNA was detected in 36 (14%) subjects, none of whom was coinfected with HBV, indicating that HBV/HCV carriers account for one-fourth of this population. Antibodies to HAV and HEV were detected in 249 (100%) and 28 (11%) subjects, respectively. Of 22 HBV DNA-positive subjects, genotype D was detected in 21 subjects and genotype F was detected in 1 subject. All 20 HDV isolates recovered from HDV RNA-positive subjects segregated into genotype I, but these differed by 2.1 to 11.4% from each other in the 522- to 526-nucleotide sequence. Of 36 HCV RNA-positive samples, 35 (97%) were genotype 1b and 1 was genotype 2a. Reflecting an extremely high prevalence of hepatitis virus infections, there were no appreciable differences in the prevalence of hepatitis virus markers between the two studied populations with distinct living place and lifestyle. A nationwide epidemiological survey of hepatitis viruses should be conducted in an effort to prevent de novo infection with hepatitis viruses in Mongolia.

* Corresponding author. Mailing address: Division of Virology, Department of Infection and Immunity, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi-Machi, Tochigi-Ken 329-0498, Japan. Phone: 81-285-58-7404. Fax: 81-285-44-1557. E-mail: hokamoto{at}jichi.ac.jp.

Clinical and Diagnostic Laboratory Immunology, March 2004, p. 392-398, Vol. 11, No. 2
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.2.392-398.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Takahashi, M., Kusakai, S., Mizuo, H., Suzuki, K., Fujimura, K., Masuko, K., Sugai, Y., Aikawa, T., Nishizawa, T., Okamoto, H. (2005). Simultaneous Detection of Immunoglobulin A (IgA) and IgM Antibodies against Hepatitis E Virus (HEV) Is Highly Specific for Diagnosis of Acute HEV Infection. J. Clin. Microbiol. 43: 49-56 [Abstract] [Full Text]  


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