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Clinical and Diagnostic Laboratory Immunology, March 2004, p. 330-336, Vol. 11, No. 2
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.2.330-336.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

D8/17 and CD19 Expression on Lymphocytes of Patients with Acute Rheumatic Fever and Tourette's Disorder

Julie L. Weisz, William M. McMahon, Jill C. Moore, Nancy H. Augustine, John F. Bohnsack, James F. Bale, Michael B. Johnson, Jubel F. Morgan, Jenise Jensen, Lloyd Y. Tani, L. George Veasy, and Harry R. Hill*

Departments of Pathology, Psychiatry, Internal Medicine, and Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84132

Received 16 June 2003/ Returned for modification 8 August 2003/ Accepted 3 December 2003

D8/17, an alloantigen found on B lymphocytes, has been reported to be elevated in patients susceptible to rheumatic fever and may be associated with autoimmune types of neuropsychiatric disorders. The pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococci model is a putative model of pathogenesis for a group of children whose symptoms of obsessive-compulsive disorder and Tourette's disorder (TD) are abrupt and may be triggered by an infection with group A streptococci. As a test of this model, we have examined D8/17 levels on the B cells of patients with TD and acute rheumatic fever (ARF) along with those on the B cells of normal controls by flow cytometry. We have utilized several different preparations of D8/17 antibody along with a variety of secondary antibodies but have been unable to show an association with an elevated percentage of D8/17-positive, CD19-positive B cells in either ARF or TD. We did find, however, that the percentages of CD19-positive B cells in ARF and TD patients were significantly elevated compared to those in normal controls. Group A streptococcal pharyngitis patients also had an elevated percentage of CD19 B cells, however. These studies failed to confirm the utility of determining the percentage of B cells expressing the D8/17 alloantigen in ARF patients or our sample of TD patients. In contrast, the percentage of CD19-positive B cells was significantly elevated in ARF and TD patients, as well as group A streptococcal pharyngitis patients, suggesting a role for inflammation and/or autoimmunity in the pathogenesis of these disorders.

* Corresponding author. Mailing address: Department of Pathology, University of Utah School of Medicine, 30 N. 1900 E. Rm 5B114, Salt Lake City, UT 84132. Phone: (801) 581-5873. Fax: (801) 585-1265. E-mail: harry.hill{at}path.utah.edu.

Clinical and Diagnostic Laboratory Immunology, March 2004, p. 330-336, Vol. 11, No. 2
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.2.330-336.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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