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Clinical and Diagnostic Laboratory Immunology, March 2004, p. 292-296, Vol. 11, No. 2
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.2.292-296.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Specific HLA-DRB and -DQB Alleles and Haplotypes Confer Disease Susceptibility or Resistance in Bahraini Type 1 Diabetes Patients

Einas M. Al-Harbi,1 Abdul-Jabbar Abbassi,2 Hala Tamim,3 Fayza al-Jenaidi,2 Mariam Kooheji,2 Madeeha Kamal,2 Salwa al-Mahroos,1 Faisal al-Nasir,1 Ayesha A. Motala,4 and Wassim Y. Almawi1*

College of Medicine, Arabian Gulf University,1 Department of Pediatrics, Salmaniya Medical Complex, Manama, Bahrain,2 Department of Epidemiology and Biostatistics, American University of Beirut, Beirut, Lebanon,3 Nelson R. Mendela School of Medicine, University of Natal, Durban, South Africa4

Received 19 October 2003/ Returned for modification 11 December 2003/ Accepted 29 December 2003

Insofar as genetic susceptibility to type 1 diabetes is associated with HLA class II genes, with certain allelic combinations conferring disease susceptibility or resistance, this study assessed the distributions of HLA-DR and -DQ among 107 unrelated patients with type 1 diabetes and 88 healthy controls from Bahrain, all of Arab origin. The HLA-DRB and -DQB genotypes were determined by PCR-sequence-specific priming. The following alleles showed the strongest association with type 1 diabetes among patients versus controls according to their frequencies: DRB1*030101 (0.430 versus 0.097; P < 0.001), DRB1*040101 (0.243 versus 0.034; P < 0.001), DQB1*0201 (0.467 versus 0.193; P < 0.001), and DQB1*0302 (0.229 versus 0.091; P < 0.001). When the frequencies of alleles in controls were compared to those in patients, negative associations were seen for DRB1*100101 (0.085 versus 0.014; P < 0.001), DRB1*110101 (0.210 versus 0.060; P < 0.001), DQB1*030101 (0.170 versus 0.075; P = 0.006), and DQB1*050101 (0.335 versus 0.121; P < 0.001). In addition, the DRB1*030101-DQB1*0201 (70.1 versus 22.7%; P < 0.001) and DRB1*030101-DQB1*0302 (21.5 versus 0.0%; P < 0.001) genotypes were more prevalent among patients, thereby conferring disease susceptibility, whereas the DRB1*100101-DQB1*050101 (20.5 versus 2.8%; P < 0.001), DRB1*110101-DQB1*030101 (28.4 versus 8.4%; P < 0.001), and DRB1*110101-DQB1*050101 (30.7 versus 0.9%; P < 0.001) genotypes were more prevalent among controls, thus assigning a protective role. These results confirm the association of specific HLA-DR and -DQ alleles and haplotypes with type 1 diabetes and may underline several characteristics that distinguish Bahraini patients from other Caucasians patients.

* Corresponding author. Mailing address: Department of Medical Biochemistry and Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 22979, Manama, Bahrain. Phone: 973-39717118. Fax: 973-271090. E-mail. wyalmawi{at}yahoo.co.uk.

Clinical and Diagnostic Laboratory Immunology, March 2004, p. 292-296, Vol. 11, No. 2
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.2.292-296.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Al-Jenaidi, F. A., Wakim-Ghorayeb, S. F., Al-Abbasi, A., Arekat, M. R., Irani-Hakime, N., Najm, P., Al-Ola, K., Motala, A. A., Almawi, W. Y. (2005). Contribution of Selective HLA-DRB1/DQB1 Alleles and Haplotypes to the Genetic Susceptibility of Type 1 Diabetes among Lebanese and Bahraini Arabs. J. Clin. Endocrinol. Metab. 90: 5104-5109 [Abstract] [Full Text]  
  • Motala, A. A., Busson, M., Al-Harbi, E. M., Khuzam, M. A. A., Al-Omari, E. M. D., Arekat, M. R., Almawi, W. Y. (2005). Susceptible and Protective Human Leukocyte Antigen Class II Alleles and Haplotypes in Bahraini Type 2 (Non-Insulin-Dependent) Diabetes Mellitus Patients. CVI 12: 213-217 [Abstract] [Full Text]  


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